Job Description
Job DescriptionSalary: $70,000 - $85,000
Reporting to theScientist I/II and closely working with the Senior Research Associate I/II,this individual will serve as an integralteammemberin the Research Department with exposure to multiple facets of research operations including program discovery and development. TheResearch Associatewillbe responsible forexecuting and analyzing lab-based and small animal experiments.
Elicio (ELTX) is a growing organization based out of the Seaport area of Boston, Massachusetts with additional staff functioning in a virtual based environment from the Greater Boston area and throughout the United States.
Major Duties/Responsibilities
- Executing and analyzing small animal experiments to evaluate immune responses to various antigen and adjuvant combinations(murine handling, injections, blood/organ collections, ex vivo tissue preparation and analysis)
- Executing and analyzing small animal experiments to evaluate anti-tumor activity of immunotherapy candidates(murine handling, tumor injections and monitoring, blood/organ collections, ex vivo tissue preparation and analysis)
- Executing assays to assess mechanisms of action underlying therapeuticactivity
- Maintaining detailed and accurate records, data graphing and presentation
- Communicatingfindingsin various forums bothintra- and interdepartmentally
- Highly productive and comfortable in a fast-paced work environment
Education & Professional Experience
Required:
- Bachelors degree in biology or related discipline
Skills:
- Murine handling techniques and injections
- Sample collection and processing: blood, spleen, lymph nodes, tumor, etc
- Experience with murine syngeneic tumor models
- Execution of ex vivo immuno-assays: multi-color flow cytometry, ELISpot/FluoroSpot, ELISA, Luminex, etc
- Tissue culture (cell culture and aseptic technique, isolation of splenocytes or lymphocytes from murine samples)
- Hands on experience within vitrohuman immune cell assays a plus
- Familiarity with pre-clinical drug development a plus
Working Conditions: Busy office/laboratory environment with frequent deadlines and interruptions
Travel: Frequent travel to animal facility required (within 3 miles of Elicio office)
Physical Requirements: Subject to periods of sitting or standing, vision is required to monitor data
Work Location: This role is onsite only
About Elicio Therapeutics
Elicio Therapeutics, Inc. (Nasdaq: ELTX) is a clinical-stage biotechnology company advancing a pipeline of novel lymph node-targeted immunotherapies for the treatment of some of the most aggressive cancers. By combining expertise in immunology and immunotherapy, Elicio is harnessing the natural power of the immune system with the AMP technology, which allows for therapeutic payloads to be delivered directly to the lymph nodes, with the goal of enhancing the immune systems cancer-fighting capabilities. By targeting cancer immunotherapies to the core of the immune response, AMP aims to optimize the lymph nodes natural ability to educate, activate and amplify cancer-specific T cells, which are essential for recognizing and eliminating tumor cells. Engineered to synchronize immunity in these highly potent sites, AMP is built to enhance the magnitude, potency, quality and durability of the immune response to drive antitumor activity. The Companys R&D pipeline includes off-the-shelf therapeutic cancer immunotherapy ELI-002, (targeting mKRAS-driven cancers) as well as ELI-007 and ELI-008 (targeting BRAF-driven cancers and p53 hotspot mutations, respectively). For more information, please visit www.elicio.com.
About the Amphiphile Platform
Elicio Therapeutics proprietary Amphiphile (AMP) platform delivers investigational immunotherapeutics directly to the brain center of the immune system the lymph nodes. Elicio believes this site-specific delivery of disease-specific antigens, adjuvants and other immunomodulators may efficiently educate, activate, and amplify critical immune cells, potentially resulting in induction and persistence of potent adaptive immunity required to treat many diseases. In preclinical models, Elicio has observed lymph node-specific engagement driving therapeutic immune responses of increased magnitude, function and durability. Elicio believes our AMP lymph node-targeted approach will produce superior clinical benefits compared to immunotherapies that do not engage the lymph nodes based upon preclinical studies. Elicios AMP platform, originally developed at the Massachusetts Institute of Technology has broad potential in the cancer space to advance a number of development initiatives through internal activities, in-licensing arrangements or development collaborations and partnerships. The AMP platform has been shown to deliver immunotherapeutics directly to the lymph nodes by latching on to the protein albumin, found in the bloodstream, as it travels to lymphatic tissue. In preclinical models, Elicio has observed lymph node-specific engagement driving immune responses of increased magnitude, function and durability.
Compensation range for this role is a base salary of $70,000 - $85,000 annually, dependent upon a number of factors including experience, education and relevant skills. Compensation also includes an annual bonus, equity, and the Company's benefits package.
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