Job Description
Job Title: Principal Research Scientist VI
Pay rate: $120-140/hr on w2
Duration: 12 Months (possible opportunity to convert to perm after contract term)
Location: Lexington, MA
About the Role
We are seeking an experienced DMPK Project Representative to provide scientific leadership in the discovery and optimization of small-molecule drug candidates. This role leads DMPK strategy across multiple therapeutic areas and collaborates closely with cross-functional scientific teams.
The ideal candidate is an ADME or PK/PD subject matter expert with a strong project-facing background and a track record of impactful scientific contributions.
Top Skills
- 3+ years in a project-facing scientific leadership role
- Expertise in ADME and/or PK/PD modeling
- Strong publication/abstract history in metabolism, drug interactions, or PK/PD modeling
Key Responsibilities
- Serve as the DMPK representative on global, cross-functional small-molecule project teams
- Provide expert guidance on experimental strategy, data interpretation, and DMPK strategy
- Lead internal and external research efforts supporting drug discovery
- Work closely with pharmacology, medicinal chemistry, and CRO teams
- Design, troubleshoot, and interpret complex DMPK experiments (in vitro, in vivo, in silico)
- Analyze sophisticated datasets and communicate findings to project stakeholders
- Ensure accurate documentation and contribute to scientific reports, manuscripts, and milestone documents
- Build collaborations with external scientific partners
- Represent the organization as a subject matter expert at scientific conferences
Qualifications
- Bachelor’s degree with 18+ years experience,
- OR Master’s degree with 12+ years,
- OR Doctoral degree with 6+ years relevant post-doc/industry experience
- Deep understanding of ADME principles; PK/PD modeling or biotransformation experience preferred
- Experience working with outsourced or hybrid ADME models is a plus
- Strong communication skills—verbal, written, and cross-functional
Ideal Candidate
You thrive in a scientifically complex, highly collaborative environment and enjoy integrating DMPK strategy to advance drug discovery programs. You’re comfortable leading projects, influencing cross-functional teams, and representing DMPK expertise internally and externally.