Job Description
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Client Overview:
Our client, a rapidly expanding biotechnology organization within a major U.S. biotech corridor, is seeking to advance their in vitro ADME and DMPK capabilities through automation and high-throughput innovation. They are currently looking to hire a Principal Scientist (High-Throughput ADME) to join their team. This organization is focused on modernizing ADME (Absorption, Distribution, Metabolism, and Excretion) platforms to accelerate small molecule drug discovery. By integrating high-throughput ADME screening, LC-MS/MS analytics, and automated laboratory systems, the company is transforming how ADME data informs medicinal chemistry and drug metabolism strategies.
Salary/Hourly Rate:
$75/hr - $90/hr
Position Overview:
The Principal Scientist (High-Throughput ADME) will lead the design and execution of advanced in vitro ADME assays to support drug metabolism and pharmacokinetics (DMPK) initiatives. The Principal Scientist (High-Throughput ADME) will play a critical role in scaling ADME screening platforms, delivering high-quality ADME data, and optimizing drug metabolism workflows to accelerate lead optimization. The Principal Scientist (High-Throughput ADME) position requires deep expertise in ADME assay development, LC-MS/MS analytics, and automated high-throughput screening technologies. The Principal Scientist (High-Throughput ADME) will collaborate closely with Medicinal Chemistry teams to ensure ADME and DMPK data drive strategic decision-making across the drug discovery pipeline. As a senior scientific leader, the Principal Scientist (High-Throughput ADME) will help modernize ADME infrastructure, enhance pharmacokinetics analysis, and strengthen in vitro ADME capabilities across multiple therapeutic programs.
Responsibilities of the Principal Scientist (High-Throughput ADME):
- High-Throughput ADME Assay Development & Automation:
- Design, develop, optimize, and validate high-throughput in vitro ADME assays, including solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction assays.
- Lead automation initiatives for ADME screening using liquid handling platforms such as Hamilton, Lynx, Bravo, and Formulatrix systems.
- Implement scalable workflows to enhance ADME throughput, DMPK data accuracy, and reproducibility across programs.
- Continuously refine ADME assay validation standards to support regulatory and scientific rigor.
- Drug Metabolism & LC-MS/MS Analysis:
- Develop and execute LC-MS/MS and acoustic mass spectrometry methods for in vitro ADME and drug metabolism studies.
- Oversee sample preparation, mass spectrometry method development, troubleshooting, and high-throughput ADME analysis.
- Analyze complex ADME and pharmacokinetics datasets, calculating intrinsic clearance, permeability coefficients, metabolic stability, and CYP inhibition parameters.
- Interpret ADME and DMPK data to guide medicinal chemistry optimization strategies.
- Present ADME findings and drug metabolism insights to cross-functional stakeholders.
- Quality, Compliance & Data Integrity:
- Maintain comprehensive documentation for ADME assays, DMPK workflows, SOPs, and electronic laboratory notebooks.
- Ensure all ADME and drug metabolism activities meet internal quality standards and laboratory safety regulations.
- Support data integrity for high-throughput ADME and pharmacokinetics reporting.
Required Experience/Skills for the Principal Scientist (High-Throughput ADME):
- Extensive hands-on experience with LC-MS/MS or acoustic mass spectrometry in high-throughput ADME environments.
- Proven track record in developing and executing automated in vitro ADME assays.
- Strong expertise in drug metabolism pathways, pharmacokinetics modeling, and DMPK strategy.
- Experience using ADME prediction software, pharmacokinetics tools, and data visualization platforms.
- Demonstrated experience scaling ADME screening operations in a biotech or pharmaceutical setting.
Preferred Experience/Skills for the Principal Scientist (High-Throughput ADME):
- Advanced laboratory automation expertise supporting ADME and DMPK workflows.
- Programming experience (Python, R, or similar) for ADME data analysis and pharmacokinetics modeling.
- Data visualization experience (Spotfire, Python, R) for ADME and drug metabolism reporting.
- Experience handling clinical samples in ADME or DMPK studies.
- Background working in or managing CRO relationships supporting ADME programs.
- Proficiency with LIMS, ELN, and electronic data capture systems for ADME and pharmacokinetics data management.
Education Requirements:
- Ph.D. in Pharmaceutical Sciences, Pharmacology, Analytical Chemistry, or a related field with 2+ years of industry experience in ADME and DMPK, OR
- Master's degree with 5+ years of relevant ADME, drug metabolism, or pharmacokinetics experience.
Benefits:
- Atrium Care Package available, upon eligibility (including healthcare plans, discount programs, and paid time off).
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As a woman-owned firm, we value diversity. We are an equal opportunity and affirmative action employer and will consider all applications without regard to race, sex (including gender, pregnancy, sexual orientation and gender identity), age, color, religion or creed, national origin or ancestry, veteran status, disability (physical or mental), genetic information, citizenship or any other characteristic protected by law. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Candidates who apply for roles through the Atrium website will be added to our candidate pool and may be considered for additional roles of a similar title. Please contact us to request an accommodation.
EOE/M/F/D/V/SO
Position ID: 160321