Director-Gene Therapy Drug Discovery Biologist

Job Description

Job Description

Job Title:

Director – Gene Therapy Drug Discovery Biologist

Reports to (title):

Senior Director, Molecular Therapeutics-Scientific Lead

Solid Summary:

Solid Biosciences is a life science company focused on advancing a portfolio of neuromuscular and cardiac programs, including SGT-003, a differentiated gene therapy candidate for the treatment of Duchenne, SGT-401, a gene therapy program for the treatment of BAG3 mediated dilated cardiomyopathy, SGT-212, a gene therapy program for the treatment of Friedreich’s Ataxia, and additional assets for the treatment of fatal cardiac diseases. Solid aims to be the center of excellence across a given disease spectrum bringing together those with expertise in science, technology, disease management, and care. Patient-focused and founded by those directly impacted, Solid’s mandate is to improve the daily lives of patients living with these devastating diseases.

Position Summary:

We are seeking a highly skilled and motivated PhD scientist to join the Molecular Therapeutics team to select our lead therapeutics. The ideal candidate will have a strong scientific background in human iPSC biology, in vivo biodistribution studies (small and large animal), protein science, molecular biology, and quantitative imaging techniques.

Key Duties & Accountabilities:

• Contribute to both the inception and selection of AAV libraries
• Optimize in vitro and in vivo models to select lead therapeutics for translation to humans
• Lead a scientific team to quantitatively compare VG, mRNA, and protein levels
• Detailed understanding of antibody and FISH imaging techniques to quantify biodistribution and expression levels
• Collaborate within the MTx Department and across the R&D organization to incorporate selected therapies into the Discovery & Translational Development pipeline
• Manage projects with outside partners from inception to completion
• Communicate findings and insights to stakeholders through presentations, patents, publications, and scientific conferences

Core Competencies Required:

• Strong track record in experimental design, molecular genetics and cellular biology, statistics, protein science, and imaging
• Leadership experience in a biotechnology/pharmaceutical company focusing on biologics drug discovery
• Proficiency in computing include Geneious, Endnote, BLAST, Ensembl, NCBI, Uniprot, UCSC, GTEx, Microsoft, PRISM statistics program, Benchling
• Strong problem-solving skills and the ability to work independently and collaboratively
• Excellent communication and presentation skills

Knowledge: Education, Experience, & Skills:

PhD in physiology/pharmacology, Post-Doctorate in vector biology preferred, with >3 years industry experience leading laboratory scientists

Travel Commitment:

Solid Biosciences, Charlestown, MA

Role Location

(HQ, Hybrid, Remote, NC, etc.)

HQ